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それ， 其れ
1. that, it
2. then, that point (in time), that time
3. there
4. you
tbd
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命にかかわる， 命に係わる， 命に関わる， いのちにかかわる
1. to be a matter of life or death
tbd
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問題， もんだい
1. question (e.g. on a test), problem
2. problem (e.g. societal, political), question, issue, subject (e.g. of research), case, matter
3. question (i.e. doubt)
4. public discussion, controversy
5. trouble, problem, inconvenience, difficulty
问题（例如在考试中），难题；麻烦、问题、不便、困难；问题（如社会性、政治性问题）、疑问、议题、课题（如研究课题）、案例、事项；疑问；公开讨论，争议
は
1. indicates sentence topic
2. indicates contrast with another option (stated or unstated)
3. adds emphasis
指示句子的主题；表示与另一选项（无论是否明确提及）形成对比；表示强调
