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にもかかわらず， にも関わらず， にも拘らず， にも拘わらず， にも関らず， にも掛かわらず
1. in spite of, nevertheless, although, despite, no matter the, regardless of
尽管，不顾
は
1. indicates sentence topic
2. indicates contrast with another option (stated or unstated)
3. adds emphasis
指示句子的主题；表示与另一选项（无论是否明确提及）形成对比；表示强调
