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損ねる, そこねる
1. to harm, to hurt, to injure, to wreck
2. to miss one's chance to (do something), to fail to (do what one ought to have done)
错失(做某事)的机会,未能(做本应做的事);伤害、伤害、致伤、毁坏
は
1. indicates sentence topic
2. indicates contrast with another option (stated or unstated)
3. adds emphasis
指示句子的主题;表示与另一选项(无论是否明确提及)形成对比;表示强调